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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Baicalein, Docetaxel
Phytochemical Name Baicalein (PubChem CID: 5281605 )
Anticancer drug Name Docetaxel (PubChem CID: 148124 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Docetaxel
Adverse Reactions Myelosuppression, acne,itching, flushing, rash. This was inferred hot nature anticancer drug.
Recommendations Cold: Plantago depressa; Scutellaria barbata; Paeonia veitchii; Plantago asiatica; Scutellaria baicalensis;
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 75
Ref_1
Pair Name Baicalein, Docetaxel
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Inhibition-->Tumor angiogenesis
Gene Regulation Down-regulation Phosphorylation AKT1 hsa207
Down-regulation Expression CCNB1 hsa891
Down-regulation Expression CCND1 hsa595
Down-regulation Expression CDC25C hsa995
Down-regulation Expression CDK4 hsa1019
Down-regulation Expression CDK6 hsa1021
Down-regulation Expression CTNNB1 hsa1499
Up-regulation Phosphorylation GSK3B hsa2932
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
Result Baicalein enhances the antitumor efficacy of docetaxel on nonsmall cell lung cancer in a β-catenin-dependent manner
03. Reference
No. Title Href
1 Baicalein enhances the antitumor efficacy of docetaxel on nonsmall cell lung cancer in a β-catenin-dependent manner. Phytother Res. 2020 Jan;34(1):104-117. doi: 10.1002/ptr.6501. Click
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